More Evidence Diabetes Drug Actos Raises Bladder Cancer Risk a Bit

Title: More Evidence Diabetes Drug Actos Raises Bladder Cancer Risk a Bit
Category: Health News
Created: 3/30/2016 12:00:00 AM
Last Editorial Review: 3/31/2016 12:00:00 AM

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25 Legends: Hillary Liber

This year marks the 25^th anniversary of two American Diabetes Association^® signature fundraising events—Step Out: Walk to Stop Diabetes^® and Tour de Cure^®.

Every dollar raised at these events supports people living with diabetes and funds our life-changing research and programs.

The “25 Legends” blog series highlights personal stories from some of the Association’s most dedicated walkers and riders who live with the disease.

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I am turning 63 years old this month and I currently live in San Diego. I have been living
with type 1 diabetes for 25 years.

When I was first diagnosed, I was terrified. My doctor recognized my fear, held my hands in his and asked me what scared me. I told him about my two uncles who had type 1 diabetes. The first was blind and had both of his legs amputated from his knees down. The other died in his 40s. I knew them when they were once just like me—healthy and full of life.

I wondered if their fate would be mine. My doctor promised me it would not, and he was right! All these years later, my only complication has been cataracts.

The American Diabetes Association helped me get through many things, including understanding the differences and similarities between type 1 and type 2 diabetes. They also taught me about insulin pumps and helped me switch from eight injections a day to two pump insertions a week.

The Association is helping everyone manage their diabetes on a daily basis. They support our loved ones with education, family activities and camp programs, and funding leading-edge research in diabetes prevention, treatment and probable cures. It’s my goal to help others the way the Association helped me.

I began walking in Step Out: Walk to Stop Diabetes in 1995 and was proud to raise $750! My team, Hillary’s Havurah, has been supporting me for the past 18 years. “Havurah” in Hebrew means fellowship and coming together for a purpose—in this case, to Stop Diabetes. Each year, I send out 700 letters and 400 emails, and together we raise an average of $15,000. In our best year, we topped $20,000!

Our fundraising goal is always $18,000 because 18 in Hebrew is “Chai,” which means life. We like to say, “We saved 1,000 lives.” Our Step Out team wants a world that is diabetes free, so we work every day to Stop Diabetes! Whether it’s through advocating in our communities and government, educating everyone we meet or raising funds, we support the Association’s great work.

Please join us at a Step Out event! We want you to push us out of the No. 1 fundraising spot in San Diego! It takes sincere effort and lots of dedication, but you can do it.

Unfortunately as many as 1 in 3 American adults will have diabetes by 2050 if present
trends continue. Everyone knows someone with diabetes, and everyone wants to fight it. So just ask them to contribute and provide them the opportunity to help!

Together, we CAN Stop Diabetes.

 

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The Association is so grateful of our 25 Legends! Their tireless efforts as walkers and riders are a tremendous support and inspiration to people with diabetes.

Sign up today! Learn more about these events and find out how to get involved at diabetes.org/stepout and http://ift.tt/1qKFQGM.

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Matrix metalloproteinases in the wound microenvironment

Krejner A, Litwiniuk M, Grzela T

Source Chronic Wound Care Management and Research http://ift.tt/1MRurys

Your Rights, One Voice: Ashlynn’s Story

Education about diabetes and its care can sometimes make a big difference.

The CREST program, run by the city of Santa Monica, California, adds learning adventures to the lives of children who attend the program. This city-funded program provides enrichment classes, including music, art, theater and sports to children in grades K-5. Nine-year-old Ashlynn had been participating in the program since she was five, playing volleyball and participating in track and field.

The program feared liability after Ashlynn’s type 1 diabetes diagnosis.

But in April 2015, Ashlynn was diagnosed with type 1 diabetes and her access to CREST activities became more limited. Ashlynn’s mother, Audrey, learned that the program would not train its staff to administer glucagon. Glucagon is sometimes necessary when a person with diabetes experiences extremely low blood glucose, also known as hypoglycemia. Without trained staff around, Ashlynn would not be fully protected during program activities, unless her mother could also be there to provide it. Audrey was told the City of Santa Monica feared a lawsuit if its staff did not administer glucagon correctly—and that was the reason for this policy.

Ashlynn loved being part of the CREST program. 

Audrey, a single mother who could not always be there the entire time, worried that if the CREST staff was not able to provide glucagon when it was needed, Ashlynn could not attend. This was not acceptable. So Audrey contacted the program directors and tried to educate them about diabetes care. She also stressed that it would not endanger Ashlynn’s life if someone gave her glucagon, even if she didn’t need it.

But the program’s policy still did not change. Ashlynn was only able to attend CREST when Audrey could also be there. That meant that Ashlynn had to miss out on many activities she loved.

Audrey contacted the American Diabetes Association® for help.

She confirmed that Ashlynn had the legal right to fully participate in the program. A legal advocate at the Association gave Audrey some information and guidance. Audrey then wrote a letter to the program that outlined Ashlynn’s rights and addressed the program’s concerns about its legal responsibility.

Things turned around.

The directors of CREST program changed the policy and agreed to train their staff about type 1 diabetes, diabetes care (including glucagon administration) and the signs and symptoms of hypoglycemia. Ashlynn would be able to fully attend the program once again.

Audrey’s experience working on this issue was a positive one. She says that the program’s directors were nothing but gracious through the whole process. And the result was what she wanted for Ashlynn.

Audrey’s advice

The Association is here to help. You can fight discrimination when you understand the laws that protect people with diabetes and can educate others about diabetes care. Sometimes information and negotiation go a long way.

“Thank you to the American Diabetes Association’s legal advocate for her time, effort and expertise,” says Audrey Berry. “When you see your child triumph through the daily struggles of managing type 1 diabetes, you will go to great lengths to ensure his or her well-being. For every parent out there who feels defeated by the weight of advocating for your child, remind yourself that there are people out there who will help. When you feel like you are going through a rough journey all by yourself, stay true to yourself and true to your cause. The city of Santa Monica, the American Diabetes Association and I worked positively together to achieve the best outcome for my daughter Ashlynn. For this I am grateful.”

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The American Diabetes Association leads the effort to prevent and eliminate discrimination against people with diabetes at school, at work and in other parts of daily life. If you need help, call 1-800-DIABETES or visit http://ift.tt/1zCIiW2.

Through our nationwide Safe at School program, the Association is dedicated to making sure that all children with diabetes are medically safe at school and have the same educational opportunities as their peers. Visit our Safe at School website for information and resources.

Give the gift of fairness — donate now to help people with diabetes facing discrimination, just like Ashlynn.

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Hormone Exposure in Womb May Boost Later Type 2 Diabetes Risk

Title: Hormone Exposure in Womb May Boost Later Type 2 Diabetes Risk
Category: Health News
Created: 3/24/2016 12:00:00 AM
Last Editorial Review: 3/25/2016 12:00:00 AM

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Health Tip: Setting Goals for a Healthier Lifestyle

Title: Health Tip: Setting Goals for a Healthier Lifestyle
Category: Health News
Created: 3/24/2016 12:00:00 AM
Last Editorial Review: 3/24/2016 12:00:00 AM

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Euglycemia Restoration by Central Leptin in Type 1 Diabetes Requires STAT3 Signaling but Not Fast-Acting Neurotransmitter Release

Central leptin action is sufficient to restore euglycemia in insulinopenic type 1 diabetes (T1D); however, the underlying mechanism remains poorly understood. To examine the role of intracellular signal transducer and activator of transcription 3 (STAT3) pathways, we used LepRs/s mice with disrupted leptin-phosphorylated STAT3 signaling to test the effect of central leptin on euglycemia restoration. These mice developed streptozocin-induced T1D, which was surprisingly not associated with hyperglucagonemia, a typical manifestation in T1D. Further, leptin action on euglycemia restoration was abrogated in these mice, which was associated with refractory hypercorticosteronemia. To examine the role of fast-acting neurotransmitters glutamate and -aminobutyric acid (GABA), two major neurotransmitters in the brain, from leptin receptor (LepR) neurons, we used mice with disrupted release of glutamate, GABA, or both from LepR neurons. Surprisingly, all mice responded normally to leptin-mediated euglycemia restoration, which was associated with expected correction from hyperglucagonemia and hyperphagia. In contrast, mice with loss of glutamate and GABA appeared to develop an additive obesity effect over those with loss of single neurotransmitter release. Thus, our study reveals that STAT3 signaling, but not fast-acting neurotransmitter release, is required for leptin action on euglycemia restoration and that hyperglucagonemia is not required for T1D.

Source Diabetes Pathophysiology http://ift.tt/1VHQBuv

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum

Proinsulin folding within the endoplasmic reticulum (ER) remains incompletely understood, but it is clear that in mutant INS gene–induced diabetes of youth (MIDY), progression of the (three) native disulfide bonds of proinsulin becomes derailed, causing insulin deficiency, β-cell ER stress, and onset of diabetes. Herein, we have undertaken a molecular dissection of proinsulin disulfide bond formation, using bioengineered proinsulins that can form only two (or even only one) of the native proinsulin disulfide bonds. In the absence of preexisting proinsulin disulfide pairing, Cys(B19)-Cys(A20) (a major determinant of ER stress response activation and proinsulin stability) preferentially initiates B-A chain disulfide bond formation, whereas Cys(B7)-Cys(A7) can initiate only under oxidizing conditions beyond that existing within the ER of β-cells. Interestingly, formation of these two "interchain" disulfide bonds demonstrates cooperativity, and together, they are sufficient to confer intracellular transport competence to proinsulin. The three most common proinsulin disulfide mispairings in the ER appear to involve Cys(A11)-Cys(A20), Cys(A7)-Cys(A20), and Cys(B19)-Cys(A11), each disrupting the critical Cys(B19)-Cys(A20) pairing. MIDY mutations inhibit Cys(B19)-Cys(A20) formation, but treatment to force oxidation of this disulfide bond improves folding and results in a small but detectable increase of proinsulin export. These data suggest possible therapeutic avenues to ameliorate ER stress and diabetes.

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Tips for Managing Type 1 and 2 Diabetes at Home

Title: Tips for Managing Type 1 and 2 Diabetes at Home
Category: Diseases and Conditions
Created: 9/6/1999 12:00:00 AM
Last Editorial Review: 3/22/2016 12:00:00 AM

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A Wearable Patch Might Help Manage Diabetes Painlessly

Title: A Wearable Patch Might Help Manage Diabetes Painlessly
Category: Health News
Created: 3/21/2016 12:00:00 AM
Last Editorial Review: 3/22/2016 12:00:00 AM

Source MedicineNet Diabetes General http://ift.tt/1UjKi18

Metabolic Syndrome

Title: Metabolic Syndrome
Category: Diseases and Conditions
Created: 4/25/2005 12:00:00 AM
Last Editorial Review: 3/17/2016 12:00:00 AM

Source MedicineNet Diabetes General http://ift.tt/1nT4gkt

Diabetes Urine Tests

Title: Diabetes Urine Tests
Category: Procedures and Tests
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 3/15/2016 12:00:00 AM

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Eating Heathy With Diabetes grocery tour at my local Vons

By Marie Feldman RD, CDE Author: The Big Book of Diabetes Recipes (Adams Media January 2016) Blog: http://ift.tt/1Uea6Lj This past Saturday I had the wonderful opportunity to conduct an Eating Heathy With Diabetes grocery tour at my local Vons. Being that this was the first tour I had ever conducted, I didn’t know quite what to expect and was both nervous and excited to embark upon the experience! The outcome was actually fantastic and the participants AND I both learned a lot. We started out in a cozy conference room with some snacks and enjoyed a great overview of diabetes by the Vons pharmacist also leading the tour. Then she kindly introduced me and I went over some of the basics about diabetes nutrition, carb counting and reading labels. After that we set out on the 90 minute walking tour and boy did time fly! I went through every section of the store and highlighted key points about the different food categories, suggested good choices and specific products with attention to labels, as well. It was really fun to hear all the great questions and comments from the 12 participants. We actually had the bonus of both a manager and [...]

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Glucose Tolerance Test

Title: Glucose Tolerance Test
Category: Procedures and Tests
Created: 3/23/2005 12:00:00 AM
Last Editorial Review: 3/14/2016 12:00:00 AM

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Grocery Shopping With Your “A” Game

Grocery shopping is one of the most important times for you to make good choices about how you will support good health through the foods you eat. In the grocery store, you’re ‘game on.’ Your choices matter, and your potential for a successful week is riding on the decisions you make in the store. The food you put in your cart and bring home is the food that you will eat. Choosing the right foods sets the stage for the type of week you will have, and how well you will maintain a healthy lifestyle. In a 2015 survey, U.S. consumers were asked how many trips they make to a grocery store every week: an average of 1.5 trips a week. With so much riding on our grocery shopping, it’s critical that we know how to make the best choices. We are willing to be educated about other areas of our lives – our careers, our hobbies, how to drive a car. Take the time to learn how to make good choices in the grocery store. Do you have a typical routine for shopping at your local store? Do you shop for the same items in the same areas every [...]

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Diabetes May Raise Risk for Dangerous Staph Infection

Title: Diabetes May Raise Risk for Dangerous Staph Infection
Category: Health News
Created: 3/11/2016 12:00:00 AM
Last Editorial Review: 3/11/2016 12:00:00 AM

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Live. Work. Play: Michael’s Diabetes Story

Working for the American Diabetes Association® means making a difference for millions of people and working toward a future free of diabetes and all its burdens.

We all have a story to share. Some of us live with type 1 or type 2 diabetes, gestational diabetes or prediabetes. Others have loved ones with the disease or have lost someone to the fight.

The following are personal stories from the Association’s staff about why we are so committed to the mission to prevent and cure diabetes and to improve the lives of all people affected by diabetes.

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Michael Eisenstein
Publisher, ADA Publishing
Home Office (Alexandria, Va.)

When I received a call from the Association recruiter in December, her first question was: “Why do you want to work for the American Diabetes Association?”

“My wife, my eldest daughter, my dad and I all live with type 2 diabetes,” I answered. The words just flew out of my mouth as if I’d needed to say them for a long time.

When I was 17, my doctor of internal medicine subjected me to a not-so-fun oral glucose tolerance test. The test showed I was low-normal. He looked at me and said: “This is an indicator, along with your dad having type 2, that you will have the disease as you grow older.”

I dismissed it, thinking, “Hey, my sugar is 70 and you’re telling me I’m going to have diabetes? No way!” When you’re 17, you feel immortal. I was wrong.

The number 17 is meaningful here because 17 years ago my internist diagnosed me with type 2 diabetes. I was floored, shaking, sweating. I felt panicky and started doing research—probably not the smartest thing to do the day of diagnosis. I had two daughters and my eldest would be diagnosed a few years later. I worried how long I would be around. I thought, “Will I walk them down the aisle? Hold my grandchildren? Face amputations?”

However, I got my head together and started eating right and working out five days a week at a gym. I went for blood tests every couple of months, and my veins and fingers quickly got used to needles. The more consistent my workouts—40 tough, sweaty minutes on a treadmill—the more controlled my glucose levels became.

Today, I am doing okay. Although I do have a number of related complications that are not getting worse, but not better either.

Before I came to the Association, I did not really think about how this disease had ravaged so many in my family. My wife had gestational diabetes with our second daughter. The doctor told her it could become type 2 diabetes in time, which it did about 10 years ago. My dad gave up his driver’s license a few years back when his right foot went numb (from diabetic neuropathy) while driving; unable to feel the brakes, he hit the accelerator instead. He hit a wall and totaled his car, but fortunately, no one was hurt.

The opportunity to serve as the Association’s new publisher just blew me away. I felt a passion inside that I’d never felt before in any of my professional positions. I’ve been working here two months now and the passion grows daily. It’s quite possible I can make a difference to help my family and the hundreds of millions in the world who suffer from this insidious disease.

I cannot imagine a better job than the one I have right now. It is an honor to work here and I am proud to be an ADA-er!

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To learn more about nationwide employment opportunities and life at the Association, please visit diabetes.org/careers.

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Triggers for Hyperglycemia

Title: Triggers for Hyperglycemia
Category: Health News
Created: 3/10/2016 12:00:00 AM
Last Editorial Review: 3/10/2016 12:00:00 AM

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Doctors May Be Missing Chances to Treat Prediabetes

Title: Doctors May Be Missing Chances to Treat Prediabetes
Category: Health News
Created: 3/9/2016 12:00:00 AM
Last Editorial Review: 3/9/2016 12:00:00 AM

Source MedicineNet Diabetes General http://ift.tt/1YzTInP

Fitness in Youth May Be Key to Diabetes Risk Decades Later

Title: Fitness in Youth May Be Key to Diabetes Risk Decades Later
Category: Health News
Created: 3/7/2016 12:00:00 AM
Last Editorial Review: 3/8/2016 12:00:00 AM

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Diabetes and Foot Problems

Title: Diabetes and Foot Problems
Category: Diseases and Conditions
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 3/3/2016 12:00:00 AM

Source MedicineNet Diabetes General http://ift.tt/1plAC7H

Is Type 1 Diabetes Linked to Raised Risk of Certain Cancers?

Title: Is Type 1 Diabetes Linked to Raised Risk of Certain Cancers?
Category: Health News
Created: 3/1/2016 12:00:00 AM
Last Editorial Review: 3/2/2016 12:00:00 AM

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Stem cells and chronic wound healing

Leavitt T, Hu MS, Marshall CD, Barnes LA, Longaker MT, Lorenz HP

Source Chronic Wound Care Management and Research http://ift.tt/1nimbRg

Study Compares Drugs for Common Diabetic Eye Disease

Title: Study Compares Drugs for Common Diabetic Eye Disease
Category: Health News
Created: 2/29/2016 12:00:00 AM
Last Editorial Review: 3/1/2016 12:00:00 AM

Source MedicineNet Diabetes General http://ift.tt/1QSCdPT

Eat Well to Celebrate National Nutrition Month

Have you ever wondered, “What can I eat?”

You’re not alone! For many people, choosing foods is one of the most challenging aspects of managing diabetes. Let the American Diabetes Association® be your source of up-to-date information on nutrition. March is National Nutrition Month®— the perfect time to find delicious ways to eat well.

So, where should you start?

The most important step is finding a healthful meal plan that works for you. People often ask which diet is best for people with diabetes. But it is the position of the Association that there is no “one-size-fits-all” eating pattern. Many options can be helpful for managing diabetes, whether your choice is Mediterranean style, low fat, lower carbohydrate, vegetarian or DASH (Dietary Approaches to Stop Hypertension).

The next step?

Fill your grocery cart and your plate with “nutrient-dense” foods. Nutrient-dense foods are some of the best choices you can make: nonstarchy vegetables, fruits, lean proteins, whole grains and starchy vegetables, nonfat or low-fat dairy and healthy fats. These foods provide more vitamins, minerals and fiber for fewer calories.

Remember that it’s easy to choose nutrient-dense foods in the right portion sizes when you Create Your Plate. Fill half of it with nonstarchy vegetables, such as salad, green beans, broccoli, cauliflower, carrots and tomatoes. The other half is for your protein and starches.

Also keep in mind that the federal government’s new 2015-2020 Dietary Guidelines for Americans recommend limiting added sugars and saturated fats and reducing sodium intake. This recommendation is based on scientific evidence and is important for all Americans, including people with diabetes.

Satisfy your flavor cravings with these tips:

Avoid sugar-sweetened beverages.

• Skip regular soda, fruit punch, sports drinks, sweet tea and other sugary drinks.
• Drink water, unsweetened coffee or tea, sparkling water or other zero-calorie drinks.

Limit saturated fats by replacing them with small amounts of healthy fats. (Healthy fats are monounsaturated, polyunsaturated and omega-3 fatty acids, which can decrease your risk for heart disease.)

• Cook with liquid vegetable oils instead of butter, shortening or lard.
• Choose avocado, nuts, seeds or olives instead of cheese.
• Use trans-fat-free spreads instead of butter.

Consume less than 2,300 milligrams of sodium per day. (Your health care provider may recommend even less if you have high blood pressure.)

• Shop for lower-sodium versions if you buy canned foods, salad dressings, frozen dinners, deli meats and other processed foods. Drain and rinse canned vegetables and beans before adding them to your meals.
• Cook with less salt and more herbs and spices, such as chili powder, cilantro, parsley, basil, curry powder, ginger or thyme. Brighten up flavors with vinegar, garlic or fresh lemon or lime juice.

For more information on healthful eating, cooking tips and recipes, visit diabetes.org/recipes and sign up for Recipes for Healthy Living.

And don’t forget to join us on Wednesday, March 9, at 7 p.m. ET for our #AskTheRD Twitter chat!

Source Diabetes Stops Here http://ift.tt/1L1UOXt