Diabetes Rates Fall in Neighborhoods With Healthy Food, Parks and Gyms

Title: Diabetes Rates Fall in Neighborhoods With Healthy Food, Parks and Gyms
Category: Health News
Created: 6/29/2015 12:00:00 AM
Last Editorial Review: 6/30/2015 12:00:00 AM

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Diabetes Rates Fall in Neighborhoods With Healthy Food, Parks and Gyms

Title: Diabetes Rates Fall in Neighborhoods With Healthy Food, Parks and Gyms
Category: Health News
Created: 6/29/2015 12:00:00 AM
Last Editorial Review: 6/30/2015 12:00:00 AM

Source MedicineNet Diabetes General http://ift.tt/1KpxnDL

Living Long and Prospering with Diabetes: Alta Firman Getman

Recently we asked our Facebook community to tell us about people who have lived long and well with diabetes – people who have lived 20, 30 or even 40 years or more with the disease. Having received a lot of great responses, we’re privileged to present these favorites on the blog this week. We’re hope you’re as inspired by these personal stories as we are!

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Name: Alta Firman Getman
Age: 43 (diagnosed at 12)
Location: Seattle, Washington

I am 43 years old and have been living with type 1 diabetes for 31 years. My blood glucose levels were well over 1000 mg/dl and I weighed only 79 pounds when I was diagnosed. It’s been a long journey, but I am still going strong.

I have two healthy grown kids, I work out every day and I eat as healthfully as I can. It’s paid off because I am still complication free after all of this time! I have been a pumper for 16 years and have had a CGM (continuous glucose monitor) for just over a year. The combination has made handling diabetes much more manageable.

Being positive about my condition is the best way to handle all of the challenges of diabetes (and there are a lot of them!). I have my share of battle wounds but am living a healthy, strong life!

For me, the greatest improvements in diabetes care have been insulin pump technology and more recently the CGM. It is priceless to be able to see where your levels are trending so that you can make corrections before your levels get too high or low. Also, I went from 8 to 10 multiple daily injections before I went on the pump, so it definitely changed my life.

My main motivators for staying healthy are my kids and my fitness. Without stable levels, I would not be a healthy mom nor would I be able to work out every day. A strong, functioning body keeps me feeling good and helps keep my levels stable. After 31 years, I am still complication free and I want to keep it that way!

To someone who is newly diagnosed, I would say a few things. First, it’s okay to be mad, sad and tearful. It’s a grieving process for some, so allow yourself to go through that process.

Also, know that it WILL get frustrating because there are days that no matter what you do, your diabetes will still do its own thing. But you can’t give up. Diabetes will always be with you and giving up on it will only makes things worse.

Finally, try your best to stay positive. It’s okay to be down about it and grieve about it, but do it for a few minutes and then MOVE FORWARD. Being upset all the time will not make your diabetes go away (in fact, it could make it worse). It’s a part of your life now. Take control as best as you can – and when it doesn’t go your way, keep going anyway!

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All About Glucose Control

All About Glucose Control: A collection of articles from various sources that deal with the control and management of blood glucose.

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Order in Which Food Is Eaten May Affect Type 2 Diabetics' Blood Sugar

Title: Order in Which Food Is Eaten May Affect Type 2 Diabetics' Blood Sugar
Category: Health News
Created: 6/23/2015 12:00:00 AM
Last Editorial Review: 6/24/2015 12:00:00 AM

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Type 2 Diabetes

Title: Type 2 Diabetes
Category: Diseases and Conditions
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 6/24/2015 12:00:00 AM

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Men’s Health Month: Know Where You Stand

June is Men’s Health Month, and we at the American Diabetes Association are celebrating all the men out there who “know where they stand.”

Though Houston Texan Duane Brown does not live with diabetes himself, he is very close to the disease because his family has been directly impacted by it. As a member of our Stop Diabetes^® Celebrity Cabinet, Duane has been of great value to our mission by offering advice on the importance of healthy behavior to manage diabetes and prevent type 2 diabetes.

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1)    Why is the American Diabetes Association’s cause special to you?

It’s special to me because diabetes is an epidemic in our country and a lot of people don’t know the severity of it. Also, my family has been affected by it – so it really hits home. Bringing awareness is important to me.

2)    For Men’s Health Month we want to bring attention to the importance of scheduling and keeping doctor’s appointments. We know that men tend to procrastinate on this for various reasons, one of them being the fear of having to change their current lifestyle. Are regular medical checkups a part of your routine?

Yes, checkups are definitely part of my routine. They are very important for me because my body is how I make a living. For any man, you need to know where you stand.

3)    As a professional athlete, how important is a balanced diet to your health and career? How do you stay on top of healthy eating when tired, traveling or stressed?

I’m all about eating well and staying in good health. I work out a lot, and good nutrition is the most important aspect of being a successful athlete. I think a lot of people believe that offensive linemen eat whatever we want, but that’s not true. Eating healthy is actually very important to me.

It’s difficult to eat healthy when you’re traveling, but trying to find the best options possible is important.  Drinking a lot of water and staying away from soda and fruit drinks helps a lot as well.

4)    Exercise can help lower blood glucose, blood pressure and cholesterol—which is especially important for people with diabetes. Though you do not have diabetes, type 2 runs in your family, and physical fitness is critical for your career. How do you motivate to move on days you’re distracted or in a funk?

Those are the hardest days.  That’s the definition of mental toughness – doing things that are necessary when you don’t want to. Training, working out and preparing my body for each season have helped me acquire great discipline over the years.  I have to have the discipline to eat right and exercise so that every Sunday I’m ready.

I can be very tired or on vacation, and so on, but I always find a way to work out.  It’s helped me with my longevity and durability in my profession, so it’s something I take very seriously.

5)    Do you have a support system (friends, family and coaches) to help you stay healthy?

My coaching staff! And we have a nutritionist who does a great job of keeping healthful options around. My wife is a great support system because she cooks for me and helps me stay on track.  My teammates also do a good job of being disciplined themselves, and that helps motivate me as well.

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GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study

The role of glucose-stimulated release of GLP-1 in the development of obesity and type 2 diabetes is unclear. We assessed GLP-1 response to oral glucose in a large study population of lean and obese men and women with normal and impaired glucose regulation. Circulating concentrations of glucose, insulin, and GLP-1 during an oral glucose tolerance test (OGTT) were analyzed in individuals with normal glucose tolerance (NGT) (n = 774), prediabetes (n = 525), or screen-detected type 2 diabetes (n = 163) who attended the Danish ADDITION-PRO study (n = 1,462). Compared with individuals with NGT, women with prediabetes or type 2 diabetes had 25% lower GLP-1 response to an OGTT, and both men and women with prediabetes or type 2 diabetes had 16–21% lower 120-min GLP-1 concentrations independent of age and obesity. Obese and overweight individuals had up to 20% reduced GLP-1 response to oral glucose compared with normal weight individuals independent of glucose tolerance status. Higher GLP-1 responses were associated with better insulin sensitivity and β-cell function, older age, and lesser degree of obesity. Our findings indicate that a reduction in GLP-1 response to oral glucose occurs prior to the development of type 2 diabetes and obesity, which can have consequences for early prevention strategies for diabetes.

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Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy

Increasing prevalence of type 2 diabetes in women of childbearing age has led to a higher incidence of diabetes-associated birth defects. We established a model of type 2 diabetic embryopathy by feeding 4-week-old female mice a high-fat diet (HFD) (60% fat). After 15 weeks on HFD, the mice showed characteristics of type 2 diabetes mellitus (DM) and were mated with lean male mice. During pregnancy, control dams fed a normal diet (10% fat) were maintained on either normal diet or HFD, serving as a control group with elevated circulating free fatty acids. DM dams produced offspring at a rate of 11.3% for neural tube defect (NTD) formation, whereas no embryos in the control groups developed NTDs. Elevated markers of oxidative stress, endoplasmic reticulum stress, caspase activation, and neuroepithelial cell apoptosis (causal events in type 1 diabetic embryopathy) were observed in embryos of DM dams. DM dams treated with 200 mg/kg metformin in drinking water ameliorated fasting hyperglycemia, glucose intolerance, and insulin resistance with consequent reduction of cellular stress, apoptosis, and NTDs in their embryos. We conclude that cellular stress and apoptosis occur and that metformin effectively reduces type 2 diabetic embryopathy in a useful rodent model.

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GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R

Obesity and diabetes are characterized by increased inflammation reflecting disordered control of innate immunity. We reveal a local intestinal intraepithelial lymphocyte (IEL)-GLP-1 receptor (GLP-1R) signaling network that controls mucosal immune responses. Glp1r expression was enriched in intestinal IEL preparations and copurified with markers of Tαβ and T IELs, the two main subsets of intestinal IELs. Exendin-4 increased cAMP accumulation in purified IELs and reduced the production of cytokines from activated IELs but not from splenocytes ex vivo. These actions were mimicked by forskolin, absent in IELs from Glp1r^–/– mice, and attenuated by the GLP-1R agonist exendin (9-39) consistent with a GLP-1R–dependent mechanism of action. Furthermore, Glp1r^–/– mice exhibited dysregulated intestinal gene expression, an abnormal representation of microbial species in feces, and enhanced sensitivity to intestinal injury following administration of dextran sodium sulfate. Bone marrow transplantation using wild-type C57BL/6 donors normalized expression of multiple genes regulating immune function and epithelial integrity in Glp1r^–/– recipient mice, whereas acute exendin-4 administration robustly induced the expression of genes encoding cytokines and chemokines in normal and injured intestine. Taken together, these findings define a local enteroendocrine-IEL axis linking energy availability, host microbial responses, and mucosal integrity to the control of innate immunity.

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Adaptation of {beta}-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance

High-carbohydrate diets have been associated with β-cell strain, dyslipidemia, and endothelial dysfunction. We examined how β-cell and endothelial function adapt to carbohydrate overloading and the influence of insulin resistance. On sequential days in randomized order, nondiabetic subjects (classified as insulin-sensitive [IS] [n = 64] or insulin-resistant [IR] [n = 79] by euglycemic clamp) received four mixed meals over 14 h with either standard (300 kcal) or double carbohydrate content. β-Cell function was reconstructed by mathematical modeling; brachial artery flow-mediated dilation (FMD) was measured before and after each meal. Compared with IS, IR subjects showed higher glycemia and insulin hypersecretion due to greater β-cell glucose and rate sensitivity; potentiation of insulin secretion, however, was impaired. Circulating free fatty acids (FFAs) were less suppressed in IR than IS subjects. Baseline FMD was reduced in IR, and postprandial FMD attenuation occurred after each meal, particularly with high carbohydrate, similarly in IR and IS. Throughout the two study days, higher FFA levels were significantly associated with lower (incretin-induced) potentiation and impaired FMD. In nondiabetic individuals, enhanced glucose sensitivity and potentiation upregulate the insulin secretory response to carbohydrate overloading. With insulin resistance, this adaptation is impaired. Defective suppression of endogenous FFA is one common link between impaired potentiation and vascular endothelial dysfunction.

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Salt Can Be Bad For Your Overall Heart Health

As part of a heart healthy lifestyle, you may be told to lower your sodium (salt) intake in order to reduce your risk of high blood pressure. However, salt may be bad for your heart health in ways you have never thought of before. A new study published in the Journal of the American College of Cardiology found that high salt intake may actually affect the structure and function of your heart and kidneys over time. Researchers at the University of Delaware found that a high-salt meal plan may, over time, lead to problems with your immune system. This can make you more likely to get sick. It may also lead to lowered blood clotting and increased artery stiffness, which can put you at a high risk for heart attack and stroke. Even if you do not have high blood pressure, the researchers of this study say that high salt intake over time can lead to serious health problems. So talk to your healthcare provider about lowering your sodium intake to about 2300 milligrams a day, as suggested by the United States Department of Agriculture’s Dietary Guidelines. One of the best ways to eat less salt is to lower your intake [...]

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Losing Weight Can Ease Obstructive Sleep Apnea

  People with diabetes have a higher risk for sleep apnea, a condition in which your breathing stops and starts many times during the night. As this prevents you from getting a good night’s sleep, it puts you at a high risk for sleepiness during the day, memory and attention problems, insulin resistance, and even heart disease. Obstructive sleep apnea (OSA) is the most common type of this condition, and it usually affects people who are older or overweight. The good news is that a recent study found that people with OSA can manage the condition well by changing their lifestyle. The study, which was published in CHEST Journal, looked to see whether losing weight with certain lifestyle changes helped people with OSA feel more awake during the day. The Chinese researchers tracked 104 people with moderate to severe OSA. For one year, they were either given the standard treatment, or extra help from a dietitian. Those in the dietitian group were able to work with healthcare professionals specifically to change their eating and exercise habits. By the end of the study, the subjects in the dietitian group lowered their BMI and had a more balanced meal plan that included [...]

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Exercise May Have Benefits Beyond Fitness in Type 2 Diabetes

Title: Exercise May Have Benefits Beyond Fitness in Type 2 Diabetes
Category: Health News
Created: 6/17/2015 12:00:00 AM
Last Editorial Review: 6/18/2015 12:00:00 AM

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Your Rights, One Voice: Haley’s Story

Haley Doyle is a vibrant young woman in her early 20s who was diagnosed with diabetes halfway through her plebe (freshman) year at the United States Naval Academy.

Sadly for Haley, the Navy recommended that she be “separated” (dismissed) from the Academy, despite the fact that she was a varsity rower on the school’s crew team and had above-average grades.

Feeling that she was being treated unfairly, just because she has diabetes, Haley reached out to the American Diabetes Association for help.  

With the help of the Association’s Legal Advocacy program, Haley learned about her rights. And she refused to take “no” for an answer. Along with support from her parents, friends and coaches, Haley fought through medical boards to stay at the Naval Academy.

As a result, Haley was able to stay in school and achieve her dream of graduating from the Naval Academy with the Class of 2014.

Unfortunately, the Navy wouldn’t commission Haley because she has diabetes. That meant that she could not pursue the next part of her dream: to serve her country as a U.S. Navy Pilot.

A New Path

Instead, she had to take a different, but still exciting, path. Haley now works as an independent contractor for the U.S. Naval Academy, on a NASA-funded project that is headed to the International Space Station in 2016.

“The support I received from the American Diabetes Association gave me confidence to fight for what I believed in,” says Haley. “I couldn’t let go of the Naval Academy; I had worked so hard to get there and made so many lifelong friends. The thought of being kicked out for having type 1 diabetes, something beyond my control, was heartbreaking. It just wasn’t an option.”

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The American Diabetes Association leads the effort to prevent and eliminate discrimination against people with diabetes at school, at work and in other parts of daily life. If you need help, call 1-800-DIABETES or visit http://ift.tt/1zCIiW2.

Give the gift of fairness — donate now to help people with diabetes facing discrimination, just like Haley:

 

 

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Tight Food Budget Can Wreak Havoc on Diabetes Management

Title: Tight Food Budget Can Wreak Havoc on Diabetes Management
Category: Health News
Created: 6/11/2015 12:00:00 AM
Last Editorial Review: 6/12/2015 12:00:00 AM

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Chia seeds may help lower heart health risks

Eating plenty of fiber can help you reach and stay at a healthy weight, absorb more nutrients from the foods you eat, and to help keep your blood glucose levels stable. If you're looking to add some variety to the usual sources of fiber, chia seeds are something else to try.

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Efficacy of dressings for heavily exuding chronic wounds

Wiegand C, Tittelbach J, Hipler UC, Elsner P

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Health Tip: If You Have Peripheral Neuropathy

Title: Health Tip: If You Have Peripheral Neuropathy
Category: Health News
Created: 6/9/2015 12:00:00 AM
Last Editorial Review: 6/9/2015 12:00:00 AM

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New Trial Tests Whether TB Shot Fights Type 1 Diabetes

Title: New Trial Tests Whether TB Shot Fights Type 1 Diabetes
Category: Health News
Created: 6/9/2015 12:00:00 AM
Last Editorial Review: 6/9/2015 12:00:00 AM

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Could Diabetes Run in Your Relationship?

Title: Could Diabetes Run in Your Relationship?
Category: Health News
Created: 6/9/2015 12:00:00 AM
Last Editorial Review: 6/9/2015 12:00:00 AM

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Ways to Prevent Type 2 Diabetes

Did you know that you can prevent or delay type 2 diabetes by losing a small amount of weight? To get started, use these tips to help you move more, make healthy food choices, and track your progress. Reduce Portion Sizes Eat a half of a bagel instead of a whole bagel. Put less food on your plate. Drink a large glass of water 10 minutes before your meal so that you feel less hungry. Keep meat, chicken, turkey, and fish portions to about 3 ounces. Three ounces is about the size of a deck of cards. Share one dessert.   Eat Small Meals Use teaspoons, salad forks, or child-size utensils to help you take smaller bites and eat less. Make less food look like more by serving your meal on a salad or a breakfast plate. Eat slowly. It takes 20 minutes for your stomach to send a signal to your brain that you are full. Listen to music while you eat instead of watching TV. People tend to eat more while watching TV.   Move More Each Day Try to be active for at least 30 minutes, 5 days a week. If you are looking for a safe place to be active, contact your local parks or health department [...]

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Cut Your Risk of Chronic Disease

If you keep up with health and fitness news, you probably don’t need another reason to be active. Most people already know that exercise can help you lose weight; manage your blood glucose, blood pressure and cholesterol levels; and lower your risk for serious heart problems. But did you know that even a small amount of physical activity makes a big difference? A new study from Kaiser Permanente in Southern California has found that just a little bit of exercise can slash your risk for heart disease, diabetes and other chronic conditions–often by more than half. Read on to find out more. The research This study looked at over 600,000 people with an average age of 49. When they had appointments with their healthcare providers, they were asked how much physical activity they did every week. Based on their answers, the researchers split them into three groups: Active: At least 150 minutes of moderate or hard exercise each week Irregularly Active: Less than 150 minutes of exercise each week Inactive: No exercise They found that people in the first two groups had much lower blood glucose and blood pressure levels than those in the third group. This means that people [...]

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Type 2 Diabetes and Prediabetes

  Today, 29.1 million people (almost 10% of the US population) have diabetes, including 8.1 million who are undiagnosed. Another 86 million Americans have prediabetes, which means they have a high risk of getting type 2 diabetes. Having diabetes raises your risk for blindness, kidney failure, amputation, heart disease, cancer, and dementia. These risks can double individual healthcare costs. A balanced meal plan and regular physical activity are extremely important in treating and preventing type 2 diabetes. Ensuring that blood glucose, blood pressure, and cholesterol are within healthy ranges also makes a big difference. Because diabetes care and prevention is now better than ever, rates of complications–notably heart disease–have gone down. But diabetes management is not as effective as it could be, especially among poor and/or minority populations. Testing for diabetes and prediabetes Because the risk for type 2 diabetes goes up with age, all people over 45 should be tested regularly. You should also be tested every year if you are overweight and have one or more of the following risk factors: High blood glucose and/or A1C High triglycerides PCOS (polycystic ovarian syndrome) Dark, velvety patches of skin around the neck, elbows, groin and/or armpits High blood pressure A [...]

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Live from #2015ADA!

The American Diabetes Association’s 75th Scientific Sessions, the largest diabetes meeting in the world, is happening right now in Boston!

We’re excited to bring you the latest diabetes research news — with a focus on what it all means for people affected by diabetes.

Tune in to our YouTube channel for full coverage from the meeting. And if you’re on Twitter, follow #2015ADA!

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Tight Blood Sugar Control Helps the Heart in Type 2 Diabetes

Title: Tight Blood Sugar Control Helps the Heart in Type 2 Diabetes
Category: Health News
Created: 6/3/2015 12:00:00 AM
Last Editorial Review: 6/4/2015 12:00:00 AM

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Role of topical zinc in treating chronic venous leg ulcers

Maher SF

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Why I Am A Diabetes Researcher (part 2)

With our 75th Scientific Sessions right around the corner (speaking of, we hope to see you there, or you can follow #2015ADA!), we’re taking time to mark the occasion with our new “Why I am a diabetes researcher” series.

Today we hear from two more diabetes researchers. Join us as they share their journeys and insights into the past, present and future of diabetes research.

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Dr. Christoph Buettner hails from Germany. He earned MD and PhD degrees from Ludwig Maximilians University in Munich. After some residency training in internal medicine at the Klinikum Innenstadt Hospital in Munich, he came to the U.S. to complete a research fellowship at Brigham and Women’s Hospital, Harvard Medical School, residency in internal medicine at Bellevue Hospital and Harbor Health Care System, New York University and a fellowship in endocrinology, diabetes and metabolism at Montefiore Hospital and Albert Einstein College of Medicine.

He is currently Associate Professor of Medicine, Endocrinology, Diabetes and Bone Diseases and the Associate Director of Type 2 Diabetes Research at Mt. Sinai Medical Center in New York. Here, he explains his commitment to diabetes:

“My father has just recently been diagnosed with type 2 diabetes. He also has been morbidly obese for more than two decades. Besides having a predisposition for type 2 diabetes and a love of good food, I have been fascinated by the quality of the research in the field of diabetes.

“The progress in our field has been astounding. A particular interesting area I find the connection of neurobiology and metabolism that has become more appreciated after the discovery of the hormone leptin in 1994. I am amazed on a daily basis by all the publications that highlight the potent role that the brain plays in controlling metabolism. To me this interconnection between the brain and the periphery is the modern version of the ancient theme of body and mind interplay.

“We live in a point of time where sophisticated methods allow us to probe old questions on an unprecedented level of analysis and it is a thrill to participate in this undertaking. The career development award will allow me to extend my studies into the control of innate immunity by the brain. It also is critically important to support my lab and the people that work with me.

“I also cannot stress enough how important the support is that the American Diabetes Association provides to scientists that have dedicated their work to metabolism and diabetes. In times of shrinking NIH budgets this support is essential and therefore I am happy to support the Association in any way I can, whether it is by reviewing grants for the Association, papers for the scientific journals such as Diabetes, organizing meetings or educating colleagues and the public or riding the Tour de Cure.”

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Dr. Kieren Mather earned his bachelor’s and medical degrees at the University of Calgary in Canada. His residency training was conducted at the University of British Columbia and Fellowships in Endocrinology and Metabolic Research were conducted at the University of Calgary and Indiana University. He is currently Professor, Department of Internal Medicine at Indiana University.

Here, he explains his commitment to diabetes:

“My research focus is on vascular disease in diabetes, and I have been involved in diabetes research from the earliest stages of my research training. One of the defining awards for my career was an American Diabetes Association Career Development Award, which provided an important springboard to my current career. With the help of this head start, I have found good success in contributing to advances in our knowledge of micro and macrovascular disease in diabetes, and knowledge of how diabetes prevention contributes to reductions in these important diabetes complications.

“My personal expertise is in the field of complications. In my opinion, some truly groundbreaking advances have been made recently using molecular studies, and a number of these now need to be formally tested in clinical settings. Such studies should provide real advances regarding the prevention of microvascular complications. Regarding preventing macrovascular complications, it is my opinion that these advances will prove to be necessary but not sufficient, as the pathogenesis of macrovascular disease reflects a number of features of insulin resistance and diabetes beyond hyperglycemia. Pre-clinical and physiological studies still need to be done to better understand the interactions of factors in this multifactorial process, so as to better understand where the upstream ‘branch points’ are.

“By addressing key upstream steps to block multiple paths to disease, hopefully we can find a therapeutic approach which is not only necessary but sufficient to prevent macrovascular disease. Clinical testing of these notions will be a real challenge in the context of what is currently known about the prevention of macrovascular disease, and will need a careful and thoughtful approach to study design.”

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Why I Am A Diabetes Researcher

With our 75th Scientific Sessions right around the corner (speaking of, we hope to see you there, or you can follow #2015ADA!), we’re taking time to mark the occasion with our new “Why I am a diabetes researcher” series.

Over the next couple of days, we’ll hear from four diabetes researchers across a variety of different fields, with a variety of different backgrounds. Join us as they share their journeys and insights into the past, present and future of diabetes research.

——————–

Bernal-Mizrachi with Margarita Jimenez-Palomares

Dr. Ernesto Bernal-Mizrachi is from Colombia, where he earned his undergraduate and medical degrees. He did his residency at the University of Miami and Fellowship in Endocrinology and Metabolism at Washington University in St. Louis. He is currently Associate Professor of Medicine at the University of Michigan and Staff Physician at the VA Medical Center in Ann Arbor, Mich.

Here, he explains his commitment to diabetes:

“Diabetes mellitus is one of the most prevalent conditions affecting human health in the 21st century. Defects in insulin producing cells at different levels are central to develop this diabetes. My laboratory has been studying the signaling pathways that regulate how insulin producing cells grow and die and how they adapt to diabetogenic conditions. It is our expectation that understanding the mechanisms involved in these processes will result in generation of novel pharmacological agents and new strategies to prevent, treat and cure diabetes.

“As a physician scientist, my experience in clinical and basic research provides a unique privilege and opportunity to extend the observations generated in the laboratory to patient care. Therefore the outcome of the work in my laboratory will benefit a substantial fraction of the population.”

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Dr. Shannon Wallet earned her bachelor’s degree in medical technology at North Carolina State University, her MT (ASCP) at Duke University and her PhD in oral biology at the University of North Carolina, Chapel Hill. She completed a post-doctoral fellowship at the University of Pittsburgh School of Medicine and is currently Associate Professor at the University of Florida, Department of Oral Biology.

Here, she explains her commitment to diabetes:

“People with type 1 and type 2 diabetes experience complications due to the effect these diseases have on the immune system. Periodontal diseases and infections of the gum tissue, are such complications. People with diabetes tend to have more severe and longer lasting periodontal disease than people who do not have diabetes. Furthermore, people with diabetes who also have periodontitis experience  more complications than those without periodontitis and treatment of periodontitis can improve control of blood sugar. Thus, finding a treatment for periodontitis that is specific for patients with diabetes is imperative for the periodontal health as well as overall long term health. 

“We strive to determine how people with diabetes respond to periodontal disease compared to individuals who do not have diabetes. Discoveries from our research will elucidate mechanisms of periodontal disease pathology among people with diabetes and will provide information necessary for the development of appropriate diagnostic, vaccine and/or therapeutic applications in the treatment of periodontal disease in people with diabetes. Implementation of these findings will ultimately result in better glycemic control and quality of life for the patient with diabetes.

“I have been involved in type 1 or type 2 diabetes research for the past 14 years, and I have always marveled and the complexity of these diseases. People living with diabetes are also living with a multitude of secondary complications. Effective therapies for diabetes-associated periodontal disease will not only reduce suffering but also improve the overall prognosis and long-term morbidity of diabetes. I am driven by the goal of improving the quality of life for these individuals until a cure for diabetes becomes a reality. 

“Diabetes research has made excellent strides in many areas including prevention and treatment through investigations of genetics, cell biology, immunology, education and behavior modification. Diabetes is not one disease. It is a family of complex multi-factorial disease processes and the future of diabetes research should reflect this knowledge. I envision a more systemic approach to diabetes research and therapies in the future. It is critical that scientists and clinicians understand the impact of diabetes complications upon patient health and society as a whole. These complications not only exacerbate metabolic defects but also present a massive burden upon the health care system.”

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How to Save the Diabetic Foot ?



Save the Diabetic Foot

A Diabetic patient becomes terribly careful regarding regular glucose watching and also the necessary medication however is ignorant regarding realizing that a minor drawback in his foot un- noticed  will in due course of your time make a serious traumatic happening in his life. 

Burning and puncture sensation of foot and Pain and discomfort within the foot whereas walking ar early signals of diabetic foot involvement, that the patient your time fails to report back to the doctor.

Therefore besides conducting routine investigations of a diabetic patient the condition of the Foot of the patient shouldn't be unnoticed. The patient should be pre-warned regarding the varied complications. A diabetic patient becomes susceptible to cardiovascular disease, Obesity, Cardio vascular  Ailments among them is hidden and unlooked disposition to Foot abcesses, ulcers, gangrene etc. The battle is won if the foot of the patient is saved by correct and timely steering by the treating doctor and different doctors.

The dreadful facet of Diabetes:

One of the foremost alarming complications of polygenic disorder is gangrene of foot and leg. around quite fifty the troubles diabetic patients suffer from peripheral pathology and twenty five who are suffering from vasculopathy and 15 August 1945 suffer from foot issues (deformity, lesion gangrene). thus quite one large integer persons with polygenic disorder ar doubtless to suffer from foot and leg issues. it's necessary to comprehend that majority of those patients are going to be aged cluster thirty five to forty five years. several of them ar doubtless to loose their legs. this may be a significant economic and social drawback. thus we have a tendency to in Bharat ought to decide answer, that is reasonable and accessible.

It has been accepted currently that solely strategy for preventing amputation of leg is to forestall foot ulcers by dominant polygenic disorder, regular check up for pathology and Vasculopathy and advise to wear correct footwear. Once pathology and Vasculopathy is diagnosed a correct and timely treatment prevents the foot lesion.

Foot ulcers and different foot issues ar one amongst the most typical causes of morbidity, vital incapacity and even mortality among the diabetics in our country.

Amputations which will be prevented:

About 50000 amputations of lower limbs ar in deep trouble diabetic gangrene once a year in Bharat, thousands go unreported. Society pays for amputation however not for saving limbs. we'd like to vary this. Slow progress in acceptive scientific ways that to save lots of the foot.

Just as stand depends on all 3 legs to square, the quality take care of diabetic ulceration of foot depends upon debriment, antibiotics and pressure relief. Failure to deal with any of those areas will cause serious complications or potential amputation.

It is adequately apparent that rural or semi-urban areas even have giant enough prevalence of polygenic disorder. it's a public health issue. in line with W.H.O. estimate there ar eight large integers of individuals are going to be plagued by polygenic disorder in Bharat out of that one crore patient's feet are going to be in danger of plagued by leg and foot ulcers. Diabetic foot forms upward of 1 third admissions in hospitals. The morbidity and quality of life once amputation is extremely painful.

Diabetic Foot Society of Bharat leads in it's crusade:

Diabetic foot Society of Bharat (DFSI) has inexhaustibly worked to coach and sensitize thousands of medical professionals UN agency wear down diabetic foot issues as a mission to forestall any amputation. Hand book of Diabetic Foot Care printed by (DFSI) in Nov. 2005 was a run away success. the massive range of informative booklts were distributed among doctors.

DFSI's Hand Book is adequate for fast understanding problems with pathology and it's assessment a way to relate risks of diabetic foot with lesion, amputation disposition so police investigation foot in danger, peripheral vascular  unwellness conservative foot salvage surgery, the necessity for higher referral and diabetic footwear. It conjointly emphasizes on the immediate care to contain and care and cure the primary contact purpose on health care. we have a tendency to hope it helps the frontline troopers of our profession, UN agency typically work with restricted facilities.

A sure-fire diabetic foot care programme focuses it's efforts on hindrance. 2 important aspects of preventive approach ar education and also the use of correct footwear. sadly, it's not uncommon for a patient to hunt a foot care recommendation solely once he or she has already developed a tangle like diabetic lesion. typically these patients have not been tested for peripheral pathology and vasculopathy or haven't been tested recently and lots of ar altogether unaware of diabetic peripheral pathology and it's associated risks. It is quite difficult to win over one that has ne'er had foot discomfort to limit their footwear option to solely those shoes that ar thought-about by health care supplier to be acceptable - this task is completed most with efficiency once a diabetic foot care team, whose members support one another and collaborate within the interest of patients.

Diabetic Foot Care may be a Team Work:

 To prevent the alarming complications of diabetic foot to make a stage requiring amputation, it's necessary that Diabetic Foot Clinic in hospital ought to have a team of specialists.

 A multidisciplinary Diabetic Foot Clinic within the hospital will cut back the quantity of Amputations and has conjointly developed as a sure-fire model of diabetic care through out the globe.

Gateway optimum health is with you on your journey to unwellness free Healthy Life designs.

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