Why I Am A Diabetes Researcher (part 2)

With our 75th Scientific Sessions right around the corner (speaking of, we hope to see you there, or you can follow #2015ADA!), we’re taking time to mark the occasion with our new “Why I am a diabetes researcher” series.

Today we hear from two more diabetes researchers. Join us as they share their journeys and insights into the past, present and future of diabetes research.

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Dr. Christoph Buettner hails from Germany. He earned MD and PhD degrees from Ludwig Maximilians University in Munich. After some residency training in internal medicine at the Klinikum Innenstadt Hospital in Munich, he came to the U.S. to complete a research fellowship at Brigham and Women’s Hospital, Harvard Medical School, residency in internal medicine at Bellevue Hospital and Harbor Health Care System, New York University and a fellowship in endocrinology, diabetes and metabolism at Montefiore Hospital and Albert Einstein College of Medicine.

He is currently Associate Professor of Medicine, Endocrinology, Diabetes and Bone Diseases and the Associate Director of Type 2 Diabetes Research at Mt. Sinai Medical Center in New York. Here, he explains his commitment to diabetes:

“My father has just recently been diagnosed with type 2 diabetes. He also has been morbidly obese for more than two decades. Besides having a predisposition for type 2 diabetes and a love of good food, I have been fascinated by the quality of the research in the field of diabetes.

“The progress in our field has been astounding. A particular interesting area I find the connection of neurobiology and metabolism that has become more appreciated after the discovery of the hormone leptin in 1994. I am amazed on a daily basis by all the publications that highlight the potent role that the brain plays in controlling metabolism. To me this interconnection between the brain and the periphery is the modern version of the ancient theme of body and mind interplay.

“We live in a point of time where sophisticated methods allow us to probe old questions on an unprecedented level of analysis and it is a thrill to participate in this undertaking. The career development award will allow me to extend my studies into the control of innate immunity by the brain. It also is critically important to support my lab and the people that work with me.

“I also cannot stress enough how important the support is that the American Diabetes Association provides to scientists that have dedicated their work to metabolism and diabetes. In times of shrinking NIH budgets this support is essential and therefore I am happy to support the Association in any way I can, whether it is by reviewing grants for the Association, papers for the scientific journals such as Diabetes, organizing meetings or educating colleagues and the public or riding the Tour de Cure.”

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Dr. Kieren Mather earned his bachelor’s and medical degrees at the University of Calgary in Canada. His residency training was conducted at the University of British Columbia and Fellowships in Endocrinology and Metabolic Research were conducted at the University of Calgary and Indiana University. He is currently Professor, Department of Internal Medicine at Indiana University.

Here, he explains his commitment to diabetes:

“My research focus is on vascular disease in diabetes, and I have been involved in diabetes research from the earliest stages of my research training. One of the defining awards for my career was an American Diabetes Association Career Development Award, which provided an important springboard to my current career. With the help of this head start, I have found good success in contributing to advances in our knowledge of micro and macrovascular disease in diabetes, and knowledge of how diabetes prevention contributes to reductions in these important diabetes complications.

“My personal expertise is in the field of complications. In my opinion, some truly groundbreaking advances have been made recently using molecular studies, and a number of these now need to be formally tested in clinical settings. Such studies should provide real advances regarding the prevention of microvascular complications. Regarding preventing macrovascular complications, it is my opinion that these advances will prove to be necessary but not sufficient, as the pathogenesis of macrovascular disease reflects a number of features of insulin resistance and diabetes beyond hyperglycemia. Pre-clinical and physiological studies still need to be done to better understand the interactions of factors in this multifactorial process, so as to better understand where the upstream ‘branch points’ are.

“By addressing key upstream steps to block multiple paths to disease, hopefully we can find a therapeutic approach which is not only necessary but sufficient to prevent macrovascular disease. Clinical testing of these notions will be a real challenge in the context of what is currently known about the prevention of macrovascular disease, and will need a careful and thoughtful approach to study design.”

Source Diabetes Stops Here http://ift.tt/1IdH8Ga

Why I Am A Diabetes Researcher

With our 75th Scientific Sessions right around the corner (speaking of, we hope to see you there, or you can follow #2015ADA!), we’re taking time to mark the occasion with our new “Why I am a diabetes researcher” series.

Over the next couple of days, we’ll hear from four diabetes researchers across a variety of different fields, with a variety of different backgrounds. Join us as they share their journeys and insights into the past, present and future of diabetes research.

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Bernal-Mizrachi with Margarita Jimenez-Palomares

Dr. Ernesto Bernal-Mizrachi is from Colombia, where he earned his undergraduate and medical degrees. He did his residency at the University of Miami and Fellowship in Endocrinology and Metabolism at Washington University in St. Louis. He is currently Associate Professor of Medicine at the University of Michigan and Staff Physician at the VA Medical Center in Ann Arbor, Mich.

Here, he explains his commitment to diabetes:

“Diabetes mellitus is one of the most prevalent conditions affecting human health in the 21st century. Defects in insulin producing cells at different levels are central to develop this diabetes. My laboratory has been studying the signaling pathways that regulate how insulin producing cells grow and die and how they adapt to diabetogenic conditions. It is our expectation that understanding the mechanisms involved in these processes will result in generation of novel pharmacological agents and new strategies to prevent, treat and cure diabetes.

“As a physician scientist, my experience in clinical and basic research provides a unique privilege and opportunity to extend the observations generated in the laboratory to patient care. Therefore the outcome of the work in my laboratory will benefit a substantial fraction of the population.”

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Dr. Shannon Wallet earned her bachelor’s degree in medical technology at North Carolina State University, her MT (ASCP) at Duke University and her PhD in oral biology at the University of North Carolina, Chapel Hill. She completed a post-doctoral fellowship at the University of Pittsburgh School of Medicine and is currently Associate Professor at the University of Florida, Department of Oral Biology.

Here, she explains her commitment to diabetes:

“People with type 1 and type 2 diabetes experience complications due to the effect these diseases have on the immune system. Periodontal diseases and infections of the gum tissue, are such complications. People with diabetes tend to have more severe and longer lasting periodontal disease than people who do not have diabetes. Furthermore, people with diabetes who also have periodontitis experience  more complications than those without periodontitis and treatment of periodontitis can improve control of blood sugar. Thus, finding a treatment for periodontitis that is specific for patients with diabetes is imperative for the periodontal health as well as overall long term health. 

“We strive to determine how people with diabetes respond to periodontal disease compared to individuals who do not have diabetes. Discoveries from our research will elucidate mechanisms of periodontal disease pathology among people with diabetes and will provide information necessary for the development of appropriate diagnostic, vaccine and/or therapeutic applications in the treatment of periodontal disease in people with diabetes. Implementation of these findings will ultimately result in better glycemic control and quality of life for the patient with diabetes.

“I have been involved in type 1 or type 2 diabetes research for the past 14 years, and I have always marveled and the complexity of these diseases. People living with diabetes are also living with a multitude of secondary complications. Effective therapies for diabetes-associated periodontal disease will not only reduce suffering but also improve the overall prognosis and long-term morbidity of diabetes. I am driven by the goal of improving the quality of life for these individuals until a cure for diabetes becomes a reality. 

“Diabetes research has made excellent strides in many areas including prevention and treatment through investigations of genetics, cell biology, immunology, education and behavior modification. Diabetes is not one disease. It is a family of complex multi-factorial disease processes and the future of diabetes research should reflect this knowledge. I envision a more systemic approach to diabetes research and therapies in the future. It is critical that scientists and clinicians understand the impact of diabetes complications upon patient health and society as a whole. These complications not only exacerbate metabolic defects but also present a massive burden upon the health care system.”

Source Diabetes Stops Here http://ift.tt/1MhXc8q

How to Save the Diabetic Foot ?



Save the Diabetic Foot

A Diabetic patient becomes terribly careful regarding regular glucose watching and also the necessary medication however is ignorant regarding realizing that a minor drawback in his foot un- noticed  will in due course of your time make a serious traumatic happening in his life. 

Burning and puncture sensation of foot and Pain and discomfort within the foot whereas walking ar early signals of diabetic foot involvement, that the patient your time fails to report back to the doctor.

Therefore besides conducting routine investigations of a diabetic patient the condition of the Foot of the patient shouldn't be unnoticed. The patient should be pre-warned regarding the varied complications. A diabetic patient becomes susceptible to cardiovascular disease, Obesity, Cardio vascular  Ailments among them is hidden and unlooked disposition to Foot abcesses, ulcers, gangrene etc. The battle is won if the foot of the patient is saved by correct and timely steering by the treating doctor and different doctors.

The dreadful facet of Diabetes:

One of the foremost alarming complications of polygenic disorder is gangrene of foot and leg. around quite fifty the troubles diabetic patients suffer from peripheral pathology and twenty five who are suffering from vasculopathy and 15 August 1945 suffer from foot issues (deformity, lesion gangrene). thus quite one large integer persons with polygenic disorder ar doubtless to suffer from foot and leg issues. it's necessary to comprehend that majority of those patients are going to be aged cluster thirty five to forty five years. several of them ar doubtless to loose their legs. this may be a significant economic and social drawback. thus we have a tendency to in Bharat ought to decide answer, that is reasonable and accessible.

It has been accepted currently that solely strategy for preventing amputation of leg is to forestall foot ulcers by dominant polygenic disorder, regular check up for pathology and Vasculopathy and advise to wear correct footwear. Once pathology and Vasculopathy is diagnosed a correct and timely treatment prevents the foot lesion.

Foot ulcers and different foot issues ar one amongst the most typical causes of morbidity, vital incapacity and even mortality among the diabetics in our country.

Amputations which will be prevented:

About 50000 amputations of lower limbs ar in deep trouble diabetic gangrene once a year in Bharat, thousands go unreported. Society pays for amputation however not for saving limbs. we'd like to vary this. Slow progress in acceptive scientific ways that to save lots of the foot.

Just as stand depends on all 3 legs to square, the quality take care of diabetic ulceration of foot depends upon debriment, antibiotics and pressure relief. Failure to deal with any of those areas will cause serious complications or potential amputation.

It is adequately apparent that rural or semi-urban areas even have giant enough prevalence of polygenic disorder. it's a public health issue. in line with W.H.O. estimate there ar eight large integers of individuals are going to be plagued by polygenic disorder in Bharat out of that one crore patient's feet are going to be in danger of plagued by leg and foot ulcers. Diabetic foot forms upward of 1 third admissions in hospitals. The morbidity and quality of life once amputation is extremely painful.

Diabetic Foot Society of Bharat leads in it's crusade:

Diabetic foot Society of Bharat (DFSI) has inexhaustibly worked to coach and sensitize thousands of medical professionals UN agency wear down diabetic foot issues as a mission to forestall any amputation. Hand book of Diabetic Foot Care printed by (DFSI) in Nov. 2005 was a run away success. the massive range of informative booklts were distributed among doctors.

DFSI's Hand Book is adequate for fast understanding problems with pathology and it's assessment a way to relate risks of diabetic foot with lesion, amputation disposition so police investigation foot in danger, peripheral vascular  unwellness conservative foot salvage surgery, the necessity for higher referral and diabetic footwear. It conjointly emphasizes on the immediate care to contain and care and cure the primary contact purpose on health care. we have a tendency to hope it helps the frontline troopers of our profession, UN agency typically work with restricted facilities.

A sure-fire diabetic foot care programme focuses it's efforts on hindrance. 2 important aspects of preventive approach ar education and also the use of correct footwear. sadly, it's not uncommon for a patient to hunt a foot care recommendation solely once he or she has already developed a tangle like diabetic lesion. typically these patients have not been tested for peripheral pathology and vasculopathy or haven't been tested recently and lots of ar altogether unaware of diabetic peripheral pathology and it's associated risks. It is quite difficult to win over one that has ne'er had foot discomfort to limit their footwear option to solely those shoes that ar thought-about by health care supplier to be acceptable - this task is completed most with efficiency once a diabetic foot care team, whose members support one another and collaborate within the interest of patients.

Diabetic Foot Care may be a Team Work:

 To prevent the alarming complications of diabetic foot to make a stage requiring amputation, it's necessary that Diabetic Foot Clinic in hospital ought to have a team of specialists.

 A multidisciplinary Diabetic Foot Clinic within the hospital will cut back the quantity of Amputations and has conjointly developed as a sure-fire model of diabetic care through out the globe.

Gateway optimum health is with you on your journey to unwellness free Healthy Life designs.

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