FDA OKs New Injectable Type 2 Diabetes Medication

Title: FDA OKs New Injectable Type 2 Diabetes Medication
Category: Health News
Created: 7/28/2016 12:00:00 AM
Last Editorial Review: 7/29/2016 12:00:00 AM

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Live. Work. Play: Lynda’s Diabetes Story

Working for the American Diabetes Association^® means making a difference for millions of people and working toward a future free of diabetes and all its burdens.

We all have a story to share. Some of us live with type 1 or type 2 diabetes, gestational diabetes or prediabetes. Others have loved ones with the disease or have lost someone to the fight.

The following are personal stories from the Association’s staff about why we are so committed to the mission to prevent and cure diabetes and to improve the lives of all people affected by diabetes.

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Lynda Jimenez
Regional Association Director, Online Marketing and Digital Engagement
Phoenix, Arizona

From Left: Lynda Jimenez and Tiffany Bennish, Step Out Committee chair, at a Step Out Walk to Stop Diabetes kickoff

During my freshman year of high school, my father was diagnosed with type 2 diabetes. His diagnosis was scary, but at the time I didn’t think much about what diabetes meant for me.

Fast-forward four years later to when I was a college freshman. I was having recurring infections, and my doctor thought they could be caused by high blood glucose, so he requested I have my A1C tested. A few days later, on a Friday, he called me and said, “Well, you have diabetes.” My A1C was 11.1.

Since it was a weekend, I was instructed to not eat any carbs and to come back in the following week. (By the way, I’ve since switched providers and have added an endocrinologist to my team.)

When I called my parents to tell them I had diabetes, I was scared. I thought that they would be disappointed in me for doing this to myself. I thought that they would be ashamed of me and my diabetes. But they were not. They were very supportive.

My dad stayed on the phone with me as I went to the corner store to try to buy some food to get me through the weekend. I was near tears reading food labels over the phone, and I kept asking him, “Can I eat this?”

Eventually my doctor gave me more information along with a prescription, and I got my blood glucose meter. I overhauled my diet and started exercising once, sometimes twice, a day. I got my blood sugars under control. But I still felt ashamed, alone and scared.

That summer I was searching online for information about diabetes resources in my area and I came across the American Diabetes Association website. I found that there was an event coming up, the Step Out Walk to Stop Diabetes. I signed up as a Team Captain.

I actively shared my story via email and social media and asked my friends and family to walk alongside me. Step Out served as a platform to motivate me to take better care of myself, and I made sure to share that as I was asking for fundraising support. To help reach my goal, I also coordinated a raffle with contributions from local companies.

A few weeks into my fundraising, I received a call from the local walk manager asking me to speak at the kickoff about my story and my fundraising success. I readily agreed! At the kickoff, I listened to other Team Captains share their stories with diabetes and I shared my story for the very first time.

I didn’t know it at the time, but sharing my story at that event would change my life.

I developed a friendship with the walk manager and she invited me to apply for an internship with the Association. I was thrilled to be assisting with the Step Out event in Phoenix.

Since that internship, I have been part-time temporary staff twice and I have held three different full-time positions at the Association. In total, I have worked and volunteered with this amazing organization for over five years.

My work has helped me accept my diagnosis and given me the passion and drive to take better care of myself.

I also love helping people who may be facing the same challenges I had back then, as a young adult suddenly faced with type 2 diabetes. My hope is to help others educate themselves on diabetes so that they may prevent or delay type 2. And if the day comes that they find themselves lost in a diagnosis, I hope to connect them with the Association to show them that they are not alone.

We are a community of support and, sometimes, as in my case, that can be life-changing.

P.S. I am happy to report that I just received my latest A1C results, and I am down to 6.3!

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To learn more about nationwide employment opportunities and life at the Association, please visit diabetes.org/careers.

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Preventing, minimizing, and managing pain in patients with chronic wounds: challenges and solutions

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Exercise May Keep Diabetes in Check During Pregnancy

Title: Exercise May Keep Diabetes in Check During Pregnancy
Category: Health News
Created: 7/27/2016 12:00:00 AM
Last Editorial Review: 7/28/2016 12:00:00 AM

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Flu Shot Tied to Fewer Hospitalizations, Deaths in Type 2 Diabetes Patients

Title: Flu Shot Tied to Fewer Hospitalizations, Deaths in Type 2 Diabetes Patients
Category: Health News
Created: 7/26/2016 12:00:00 AM
Last Editorial Review: 7/27/2016 12:00:00 AM

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Diabetes (Type 1 and Type 2)

Title: Diabetes (Type 1 and Type 2)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 7/26/2016 12:00:00 AM

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Twitter Chat Series for Diabetes Healthcare Professionals

What Is This Twitter Chat Series About? The Johnson & Johnson Diabetes Institute, in partnership with The Diabetes Influencers Network, is launching a series of Twitter chats from August through December 2016 geared to diabetes healthcare professionals. Topics will cover the gamut from using social media for career growth to helping clients accept the diagnosis of diabetes to offering guidance on healthy restaurant eating. These lively Twitter chats will be facilitated by Hope Warshaw, MMSc, RD, CDE, BC-ADM. Our first Twitter chat will take place on Thursday, August 4, 2016 from 9:00 – 10:00 pm ET, 8:00 – 9:00 pm CT, and 6:00 – 7:00 pm PT. The topic is: How to Use Social Media to Enhance Your Career Growth.  Hope Warshaw Hope Warshaw is a diabetes and nutrition consultant, freelance writer and book author. She was an early adopter of social media and uses it, particularly Twitter, to engage with her diabetes colleagues and people with and affected by diabetes. Warshaw has authored numerous consumer-focused books for the American Diabetes Association and is a contributing editor for Diabetic Living magazine. Warshaw is a Johnson & Johnson Diabetes Institute Faculty member and is serving during 2016 as president of the [...]

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Brisk Walking May Help Ward Off Diabetes

Title: Brisk Walking May Help Ward Off Diabetes
Category: Health News
Created: 7/20/2016 12:00:00 AM
Last Editorial Review: 7/21/2016 12:00:00 AM

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Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet-Induced Insulin Resistance

In the current study, we used muscle-specific TRIB3 overexpressing (MOE) and knockout (MKO) mice to determine whether TRIB3 mediates glucose-induced insulin resistance in diabetes and whether alterations in TRIB3 expression as a function of nutrient availability have a regulatory role in metabolism. In streptozotocin diabetic mice, TRIB3 MOE exacerbated, whereas MKO prevented, glucose-induced insulin resistance and impaired glucose oxidation and defects in insulin signal transduction compared with wild-type (WT) mice, indicating that glucose-induced insulin resistance was dependent on TRIB3. In response to a high-fat diet, TRIB3 MOE mice exhibited greater weight gain and worse insulin resistance in vivo compared with WT mice, coupled with decreased AKT phosphorylation, increased inflammation and oxidative stress, and upregulation of lipid metabolic genes coupled with downregulation of glucose metabolic genes in skeletal muscle. These effects were prevented in the TRIB3 MKO mice relative to WT mice. In conclusion, TRIB3 has a pathophysiological role in diabetes and a physiological role in metabolism. Glucose-induced insulin resistance and insulin resistance due to diet-induced obesity both depend on muscle TRIB3. Under physiological conditions, muscle TRIB3 also influences energy expenditure and substrate metabolism, indicating that the decrease and increase in muscle TRIB3 under fasting and nutrient excess, respectively, are critical for metabolic homeostasis.

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Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase

Mineralocorticoid receptor (MR) expression is increased in adipose tissue from obese individuals and animals. We previously demonstrated that adipocyte-MR overexpression (Adipo-MROE) in mice is associated with metabolic changes. Whether adipocyte MR directly influences vascular function in these mice is unknown. We tested this hypothesis in resistant mesenteric arteries from Adipo-MROE mice using myography and in cultured adipocytes. Molecular mechanisms were probed in vessels/vascular smooth muscle cells and adipose tissue/adipocytes and focused on redox-sensitive pathways, Rho kinase activity, and protein kinase G type-1 (PKG-1) signaling. Adipo-MROE versus control-MR mice exhibited reduced vascular contractility, associated with increased generation of adipocyte-derived hydrogen peroxide, activation of vascular redox-sensitive PKG-1, and downregulation of Rho kinase activity. Associated with these vascular changes was increased elastin content in Adipo-MROE. Inhibition of PKG-1 with Rp-8-Br-PET-cGMPS normalized vascular contractility in Adipo-MROE. In the presence of adipocyte-conditioned culture medium, anticontractile effects of the adipose tissue were lost in Adipo-MROE mice but not in control-MR mice. In conclusion, adipocyte-MR upregulation leads to impaired contractility with preserved endothelial function and normal blood pressure. Increased elasticity may contribute to hypocontractility. We also identify functional cross talk between adipocyte MR and arteries and describe novel mechanisms involving redox-sensitive PKG-1 and Rho kinase. Our results suggest that adipose tissue from Adipo-MROE secrete vasoactive factors that preferentially influence vascular smooth muscle cells rather than endothelial cells. Our findings may be important in obesity/adiposity where adipocyte-MR expression/signaling is amplified and vascular risk increased.

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Functional Brain Networks Are Altered in Type 2 Diabetes and Prediabetes: Signs for Compensation of Cognitive Decrements? The Maastricht Study

Type 2 diabetes is associated with cognitive decrements, accelerated cognitive decline, and increased risk for dementia. Patients with the metabolic syndrome, a major risk factor for diabetes, may display comparable cognitive decrements as seen in type 2 diabetes. Currently, the impact of diabetes and prediabetes on cognition and the underlying organization of functional brain networks still remain to be elucidated. This study investigated whether functional brain networks are affected in type 2 diabetes and prediabetes. Forty-seven participants with diabetes, 47 participants with prediabetes, and 45 control participants underwent detailed cognitive testing and 3-Tesla resting state functional MRI. Graph theoretical network analysis was performed to investigate alterations in functional cerebral networks. Participants with diabetes displayed altered network measures, characterized by a higher normalized cluster coefficient and higher local efficiency, compared with control participants. The network measures of the participants with prediabetes fell between those with diabetes and control participants. Lower processing speed was associated with shorter path length and higher global efficiency. Participants with type 2 diabetes have altered functional brain networks. This alteration is already apparent in the prediabetic stage to a somewhat lower level, hinting at functional reorganization of the cerebral networks as a compensatory mechanism for cognitive decrements.

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13.1 miles closer to a life free of diabetes

At 13.1 miles, half marathons aren’t for the faint of heart—the level of time, discipline and practice it takes to adequately prepare for a run that long is a good litmus test to determine if you define yourself as a runner.

Brooke Kaplan definitively falls into that category, as she recently completed the Virginia Wine Country Half Marathon on June 4, 2016. The race was held in scenic Loudoun County, about an hour away from where she lives.

After initially learning about the race through a friend, Brooke was hesitant to participate, due to the intensity of the training. But that changed when she visited the website and saw that the American Diabetes Association^® was the official nonprofit partner of Destination Races. The chance to fundraise on behalf of the organization made running in the race all the more personal for Brooke, as a person with type 1 diabetes.

As a healthy college sophomore in 2007, Brooke never thought she could be at risk for diabetes. But an appointment at the health center on campus revealed a kidney infection, UTI and blood glucose level of 388. This startling news sent Brooke to the hospital, where she was later diagnosed with type 1 diabetes. As a college student, Brooke was starting to buy and cook food for herself for the first time, and she suddenly felt “more mature and mindful of [her] food and body than most” because she had to keep blood sugars in check.

But the disease hasn’t slowed her down—as proven by her participation in Destination Races. Even prior to the race, Brooke was active, taking Zumba classes and weightlifting. The Virginia Wine Country Half Marathon was not only her first-ever half marathon, but her first run longer than a 5K. She entered into what she called a “tough” training plan, running one to three times a week, in addition to her normal exercise routine. The running intensified, too, as she added an additional mile to her run with each week leading up to the event.

Brooke was concerned about making sure her blood sugar levels during the race—during her 8- and 11-mile training runs, her blood sugar had dropped, but she didn’t realize until after the fact—but that didn’t stop her from completing it. Quick checks pre-and post-race showed that her levels stayed within the normal range. Yet even if they hadn’t, Brooke’s supportive husband was waiting for her at the finish line, ready with trail mix from the American Diabetes Association tent to make sure she’d be okay.

Brooke’s story served as the foundation for her fundraising: Using both social media and email, she shared her experiences with friends, family and Zumba classes up until race day. She spoke directly about the symptoms, complications and dangers of the disease that impacts her daily life. Brooke believes that telling a real story and educating others, over asking directly for donations, was the key factor in how she was able to raise nearly $2,500!

As for her experience during the race, Brooke says that running a half marathon was never something that she’d considered doing before, but the donations pushed her to persevere. The end of the race was breathtaking – quite literally, as she struggled for breath crossing the finish line.

But overall, Brooke said she and her fellow runners felt a “huge sense of accomplishment. It was a really tough challenge, but I’m really happy I did it.” The fact that she completed the race with diabetes “made the sense of accomplishment all the better.” That happiness is sincere, as she hopes to sign up for another race soon.

We thank Brooke for the blood, sweat, tears and hard work she’s put in on behalf of the American Diabetes Association.

Sign up for a Destination Race near you!

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Which Diabetes Drug Is Best?

Title: Which Diabetes Drug Is Best?
Category: Health News
Created: 7/19/2016 12:00:00 AM
Last Editorial Review: 7/20/2016 12:00:00 AM

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U.S. Teen Diabetes Rate Exceeds Prior Estimates

Title: U.S. Teen Diabetes Rate Exceeds Prior Estimates
Category: Health News
Created: 7/19/2016 12:00:00 AM
Last Editorial Review: 7/20/2016 12:00:00 AM

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Healthy Fats Can Help Prevent Type 2 Diabetes: Study

Title: Healthy Fats Can Help Prevent Type 2 Diabetes: Study
Category: Health News
Created: 7/19/2016 12:00:00 AM
Last Editorial Review: 7/20/2016 12:00:00 AM

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Normal Weight May Not Protect Against Diabetes

Title: Normal Weight May Not Protect Against Diabetes
Category: Health News
Created: 7/14/2016 12:00:00 AM
Last Editorial Review: 7/15/2016 12:00:00 AM

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Rising Blood Sugar Hitting More Obese Adults

Title: Rising Blood Sugar Hitting More Obese Adults
Category: Health News
Created: 7/13/2016 12:00:00 AM
Last Editorial Review: 7/14/2016 12:00:00 AM

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Pedal Away From Type 2 Diabetes

Title: Pedal Away From Type 2 Diabetes
Category: Health News
Created: 7/12/2016 12:00:00 AM
Last Editorial Review: 7/13/2016 12:00:00 AM

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All in the Family: Jessi’s Diabetes Camp Story

The American Diabetes Association^® is proud to offer its camps as a way for children living with diabetes to just be kids and enjoy traditional summer camp activities—all while learning important self-management skills from trained medical professionals and gaining self-confidence by spending time with peers who also live with diabetes.

This story comes from Jessi Thaller-Moran, a 19-year veteran of our Diabetes Camp program. Read on—then find out how to become a Camp Champion.

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I attended Camp Carolina Trails (C.C.T.) for the first time in 1997, at the age of 9—three years after I was diagnosed with type 1 diabetes. Like many of our campers, C.C.T. marked a milestone for me: It was my first week away from my family, and my first time in a community where it wasn’t “weird” that I had to take injections or eat snacks at certain times.

Cameron Thaller and Jessi Thaller-Moran at Camp Carolina Trails, circa 2003.

I don’t remember much about that week other than learning how to walk to the shower in flip flops, but by the following Saturday, I was hooked! I proudly introduced my parents to the camp’s motto (P.M.A., or “Positive Mental Attitude”), eloquently explaining that it was “a pretty big deal.”

It turned out that P.M.A., and the Diabetes Camp community, would play an even larger role in my life than I expected. My two younger siblings, Daniel and Cameron, also were diagnosed with type 1 at a young age. More recently, my cousin, Kyle, started attending C.C.T. after being diagnosed with type 1 last year. To top it all off, my wonderful mom, Julie, ended up losing her battle with a brain tumor in August 1998, just a year after my first trip to camp.

In the midst of those challenging life changes, though, the three of us kids always looked forward to camp. It was a constant in our rapidly changing lives, a week with our “diabetes family,” and probably the only time our dad slept. It gave us a week to just be kids.

That community remained an invaluable part of my life as I grew older. When I spent the summer in a Washington, D.C., “bedroom” made from a curtain strung across half of a living room, three camp friends drove all the way from North Carolina to visit me for one unforgettable trip. Two of my three bridesmaids had type 1. The surprise flash mob (!) at my wedding, which featured several camp friends, used choreography from a 1999 camp talent show act set to a Backstreet Boys song.

And perhaps the best proof of camp’s influence on my life: This June, I returned for my 19th year at C.C.T.! (These days, I’m a counselor.)

I take so much pride in the atmosphere that we foster for our campers—we show our campers the value of P.M.A. in life, in diabetes care and in personal relationships. We conquer the high ropes, summit mountains and play camp games. We share personal stories and aspirations, often in the same breath that we “talk shop” about our favorite way to adjust insulin before exercise, or the latest pump skins. Diabetes is an important part of our lives, but it does not define us.

Cameron Thaller, Kyle Thaller, Daniel Thaller and Jessi Thaller-Moran at Camp Carolina Trails, 2016.

As a now-veteran counselor, one of my favorite parts of camp is seeing the growth in campers from Sunday to Saturday, and then from year to year—campers who come with concerns about injections, but by the end of the week are interested in an insulin pump; campers who arrive homesick, but hide from their parents when it’s time to go home; campers who begin as strangers and go on to become college roommates.

Diabetes brings us together, but there is so much more to this community that makes it special.

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Want to get involved with Diabetes Camps? Become a Camp Champion! By donating to the Association’s Diabetes Camps, you’ll help Team Tackle—an initiative uniting current, former and upcoming players from all 32 professional football teams—provide life-changing experiences for children with diabetes. Learn more at http://ift.tt/1P576ut.

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Global Team Taps Into DNA Behind Type 2 Diabetes

Title: Global Team Taps Into DNA Behind Type 2 Diabetes
Category: Health News
Created: 7/11/2016 12:00:00 AM
Last Editorial Review: 7/12/2016 12:00:00 AM

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Health Tip: Caring for Foot Ulcers

Title: Health Tip: Caring for Foot Ulcers
Category: Health News
Created: 7/11/2016 12:00:00 AM
Last Editorial Review: 7/11/2016 12:00:00 AM

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Buruli ulcer: wound care and rehabilitation

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