Gastroparesis

Title: Gastroparesis
Category: Diseases and Conditions
Created: 2/21/1999 12:00:00 AM
Last Editorial Review: 2/23/2016 12:00:00 AM

Source MedicineNet Diabetes General http://ift.tt/1oAeC9F

Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice

Dipeptidyl peptidase-4 (DPP4) inhibitors used for the treatment of type 2 diabetes are cardioprotective in preclinical studies; however, some cardiovascular outcome studies revealed increased hospitalization rates for heart failure (HF) among a subset of DPP4 inhibitor–treated subjects with diabetes. We evaluated cardiovascular function in young euglycemic Dpp4^–/– mice and in older, high fat–fed, diabetic C57BL/6J mice treated with either the glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide or the highly selective DPP4 inhibitor MK-0626. We assessed glucose metabolism, ventricular function and remodeling, and cardiac gene expression profiles linked to inflammation and fibrosis after transverse aortic constriction (TAC) surgery, a pressure-volume overload model of HF. Young euglycemic Dpp4^–/– mice exhibited a cardioprotective response after TAC surgery or doxorubicin administration, with reduced fibrosis; however, cardiac mRNA analysis revealed increased expression of inflammation-related transcripts. Older, diabetic, high fat–fed mice treated with the GLP-1R agonist liraglutide exhibited preservation of cardiac function. In contrast, diabetic mice treated with MK-0626 exhibited modest cardiac hypertrophy, impairment of cardiac function, and dysregulated expression of genes and proteins controlling inflammation and cardiac fibrosis. These findings provide a model for the analysis of mechanisms linking fibrosis, inflammation, and impaired ventricular function to DPP4 inhibition in preclinical studies.

Source Diabetes Pathophysiology http://ift.tt/1QBCGWj

Hypoglycemia

Title: Hypoglycemia
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/22/2016 12:00:00 AM

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Diabetic Neuropathy

Title: Diabetic Neuropathy
Category: Diseases and Conditions
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 2/22/2016 12:00:00 AM

Source MedicineNet Diabetes General http://ift.tt/1yePzKc

Your Rights, One Voice: Kevin’s Story

Sandy of Encinitas, California, needed some help on behalf of her son Kevin, a seventh grader. Kevin, who has type 1 diabetes, had a 504 Plan in elementary school, but it didn’t carry over to his new school. He needed a new 504 Plan to ensure that he would be treated fairly, stay medically safe and have the same access to education as his peers in middle school.

In October 2015, Sandy met with the counselor and a few of Kevin’s teachers at the school. They denied Kevin a 504 Plan because his grades were “too good” and said that a 504 Plan was only needed for students with learning problems. Instead, they set up an individualized health plan (IHP) for Kevin. But Sandy knew that an IHP would not fully protect him.

Why did it matter which plan was set up for Kevin?

 An IHP is an agreement that outlines medical care for students with special health care needs. But a 504 Plan includes extra protections for people with disabilities. Diabetes is considered a disability under federal law. 504 Plans also ensure that students with disabilities receive the accommodations that they need at school, as well as equal access to school-related activities like field trips and extracurriculars.

Sandy contacted the American Diabetes Association® for help.

 One of the Association’s Legal Advocates confirmed that Kevin was protected under federal law. He gave Sandy resources to help, including a sample letter that outlined the rights of students with diabetes. Sandy felt that the school’s administrators did not fully understand laws that protect students with diabetes. She used the sample letter, added information about Kevin and sent it to the school principal. If the letter didn’t work, Sandy was prepared to file a complaint with the school district’s superintendent. But the school agreed to meet with her again.

Sandy took some helpful suggestions from the Association’s legal advocate in preparing for this meeting.

 Kevin would be attending this school for two years and then move on to high school within the same district, so she wanted to establish a good relationship with the administrators. To encourage friendly and constructive conversation, Sandy brought coffee and snacks. To help her feel confident, she also took along another parent who had more experience with the issue and understood the laws about school and diabetes.

The result?

 A 504 Plan was set up for Kevin that will cover him through high school. Sandy is glad that she fought for Kevin’s rights and knows that her efforts will also help other students with diabetes down the road.

“A lot of people were helped. Thanks to the American Diabetes Association, the resources they provided and the other parents who encouraged me. The help from the Association’s legal advocacy program was vital, and having that help at no charge was amazing. As a side note, we just sent a small donation to the Association as a thank you.”

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The American Diabetes Association leads the effort to prevent and eliminate discrimination against people with diabetes at school, at work and in other parts of daily life. If you need help, call 1-800-DIABETES or visit http://ift.tt/1zCIiW2.

Through our nationwide Safe at School program, the Association is dedicated to making sure that all children with diabetes are medically safe at school and have the same educational opportunities as their peers. Visit our Safe at School website for information and resources.

Give the gift of fairness — donate now to help people with diabetes facing discrimination, just like Kevin.

Source Diabetes Stops Here http://ift.tt/1QtnPqO

Transcript: Twitter Chat with Aviva Goldfarb To Discuss Her New Cookbook

Twitter Chat Transcript cdiabetesinfo Hi everyone! Welcome to tonight’s chat w/@DiabetesINFL and Aviva Goldfarb @thescramble #DiabetesINFL cdiabetesinfo Starting now! Join @DiabetesINFL @thescramble @primetimeparent @AmDiabetesBooks for The Six O’Clock Meal Planner #chat #DiabetesINFL diabetesinfl Good Evening! Welcome to tonight’s chat w/@DiabetesINFL and Aviva Goldfarb @CDiabetesinfo @primetimeparent @thescramble #DiabetesINFL diabetesinfl Tonight we’ll be chatting about w/Aviva Goldfarb @thescramble, CEO, cookbook author, meal planner &Today Show contributor!! #DiabetesINFL primetimeparent @DiabetesINFL @CDiabetesInfo @thescramble So glad to be here #diabetesinfl diabetesinfl Special shout out to #DiabetesINFL @tamirossrd @cravesomehealth @maureensrn @lorishemek @amypcampbell @diabetessisters @CraveSomeHealth diabetesinfl We are so fortunate to have with us @mahodorowicz, @primetimeparent @CDiabetesInfo #DiabetesINFL bridgettxrd Happy to be joining in! #diabetesinfl amypcampbell Great to be here tonight! #diabetesINFL diabetesinfl Also so happy to have #DiabetesINFL @BarbRuhsRD @AskDrBev @EatRightMama @BridgetTxRD @dentistmel @NCESDietitian @corlansky @christychomp diabetesinfl We will be giving away (5) copies of The Six O’Clock Meal Planner tonight so Tweet w/us #DiabetesINFL thescramble So glad to be part of the chat about my favorite topic–meal planning! It’s the key 2 making family dinners happen more often #DiabetesINFL diabetesinfl More #DiabetesINFL to follow @nutritionjill @BrilliantEating @fiberfriendly @LaurenPincusRD @LisaCantkier @maggiemoon_RD @DiabeticPsych diabetesinfl @thescramble We are so glad we can have you here with us to [...]

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Sleep Loss May Be Tied to Raised Diabetes Risk in Teen Boys

Title: Sleep Loss May Be Tied to Raised Diabetes Risk in Teen Boys
Category: Health News
Created: 2/13/2016 12:00:00 AM
Last Editorial Review: 2/16/2016 12:00:00 AM

Source MedicineNet Diabetes General http://ift.tt/1Qkh6p9